Self-immolative phthalate esters sensitive to hydrogen peroxide and light.
نویسندگان
چکیده
Self-immolative aryl phthalate esters were conjugated with cleavable masking groups sensitive to light and hydrogen peroxide. The phthalate linker releases the fluorescent dye 7-hydroxycoumarin upon exposure to light or H2O2, respectively, leading to an increase in fluorescence. The light-sensitive aryl phthalate ester is demonstrated as a pro-fluorophore in cultured S2 cells.
منابع مشابه
Self-immolative aryl phthalate esters.
We report that aryl phthalate esters are robust self-immolative linkers. This linker is easy to conjugate and releases output phenols upon cleaving a fluoride-sensitive mask to yield a benign phthalic acid byproduct, making these linkers potentially useful as fluoride sensors and promising for use in biological and materials applications.
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ورودعنوان ژورنال:
- The Journal of organic chemistry
دوره 79 23 شماره
صفحات -
تاریخ انتشار 2014